| 2021-06-26 14:30:0926/06/2021 | Richmond Town | 0 - 4 | Guisborough Town | Friendly | | Recap |
- |
- |
| 2021-06-30 18:30:4730/06/2021 | Guisborough Town | C - C | Yarm & Eaglescliffe | Friendly | | Recap |
- |
- |
| 2021-07-03 15:00:0403/07/2021 | Northallerton Town | C - C | Guisborough Town | Friendly | | Recap |
- |
- |
| 2021-07-10 15:00:1710/07/2021 | Stockton Town | 3 - 0 | Guisborough Town | Friendly | | Recap |
- |
- |
| 2021-07-14 19:30:1214/07/2021 | Guisborough Town | 0 - 5 | Marske United | John Butterfield Memorial Trophy | | Recap |
- |
- |
| 2021-07-17 15:00:1417/07/2021 | Thornaby | 2 - 0 | Guisborough Town | Peter Morris Memorial Trophy | | Recap |
- |
- |
| 2021-07-20 19:30:0220/07/2021 | Guisborough Town | C - C | Whitby Town | Micky Skinner Memorial Trophy | | Recap |
- |
- |
| 2021-07-24 12:30:4724/07/2021 | Redcar Town | 4 | Guisborough Town | Mo Mowlam Memorial Cup | | Recap |
- |
- |
| 2021-07-25 15:00:0925/07/2021 | Marske United | 2 - 0 | Guisborough Town | Mo Mowlam Memorial Cup | | Recap |
- |
- |
| 2021-07-31 15:00:0031/07/2021 | Guisborough Town | 0 - 1 | Bishop Auckland | Ebac Northern League Division 1 | | Recap |
363 |
Charlie Marshall |
| 2021-08-04 19:45:0004/08/2021 | Guisborough Town | 2 - 0 | Sunderland RCA | Ebac Northern League Division 1 | | Recap |
300 |
- |
| 2021-08-07 15:00:5407/08/2021 | Penrith | 1 - 2 | Guisborough Town | Emirates FA Cup | | Recap |
- |
- |
| 2021-08-11 19:45:0011/08/2021 | Guisborough Town | 0 - 2 | Ashington | Ebac Northern League Division 1 | | Recap |
271 |
- |
| 2021-08-14 15:00:0014/08/2021 | Guisborough Town | 2 - 0 | Seaham Red Star | Ebac Northern League Division 1 | | Recap |
170 |
- |
| 2021-08-21 15:00:3321/08/2021 | North Shields | 2 - 0 | Guisborough Town | Emirates FA Cup | | Recap |
275 |
Nick Hood |
| 2021-08-25 19:45:0025/08/2021 | Guisborough Town | 3 - 0 | West Allotment Celtic | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2021-08-28 15:00:0028/08/2021 | Guisborough Town | 0 - 0 | Newton Aycliffe | Ebac Northern League Division 1 | | Recap |
241 |
Callum Martin |
| 2021-08-30 11:00:0030/08/2021 | Northallerton Town | 2 - 2 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
206 |
- |
| 2021-09-04 15:00:0004/09/2021 | Billingham Town | 0 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
170 |
- |
| 2021-09-11 15:00:0211/09/2021 | Carlisle City | 1 - 0 | Guisborough Town | Buildbase FA Vase | | Recap |
146 |
- |
| 2021-09-18 15:00:0018/09/2021 | Guisborough Town | 0 - 4 | Thornaby | Ebac Northern League Division 1 | | Recap |
316 |
- |
| 2021-09-25 15:00:0025/09/2021 | Crook Town | 1 - 3 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
265 |
- |
| 2021-10-02 15:00:0002/10/2021 | Consett | 3 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
455 |
Joe Bartliff |
| 2021-10-09 15:00:0009/10/2021 | Guisborough Town | 0 - 1 | West Auckland Town | Ebac Northern League Division 1 | | Recap |
349 |
Joseph Bartliff |
| 2021-10-16 15:00:0016/10/2021 | Sunderland Ryhope C.W. | 1 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2021-10-20 19:30:0020/10/2021 | Newcastle Benfield | 0 - 2 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
121 |
- |
| 2021-10-23 15:00:0023/10/2021 | Whitley Bay | 2 - 1 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
383 |
- |
| 2021-10-30 15:00:0030/10/2021 | Guisborough Town | 0 - 4 | North Shields | Ebac Northern League Division 1 | | Recap |
261 |
- |
| 2021-11-06 15:00:0006/11/2021 | Redcar Athletic | 0 - 2 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
384 |
- |
| 2021-11-13 15:00:0013/11/2021 | Guisborough Town | 1 - 2 | Penrith | Ebac Northern League Division 1 | | Recap |
434 |
- |
| 2021-11-20 15:00:0020/11/2021 | Sunderland RCA | 1 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2021-11-24 19:45:0824/11/2021 | Guisborough Town | 1 - 1 | Middlesbrough FC U23 | North Riding Senior Cup | | Recap |
314 |
- |
| 2021-12-04 15:00:0004/12/2021 | Guisborough Town | 2 - 2 | Northallerton Town | Ebac Northern League Division 1 | | Recap |
204 |
Charlie Marshall |
| 2021-12-11 15:00:0011/12/2021 | West Allotment Celtic | 3 - 2 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
70 |
- |
| 2021-12-18 15:00:0018/12/2021 | Guisborough Town | 3 - 2 | Whickham | Ebac Northern League Division 1 | | Recap |
152 |
Charlie Marshall |
| 2022-01-12 19:45:4612/01/2022 | Guisborough Town | P - P | Crook Town | Brooks Mileson Memorial Northern League Cup | | Recap |
- |
- |
| 2022-01-15 15:00:0015/01/2022 | Guisborough Town | 4 - 1 | Newcastle Benfield | Ebac Northern League Division 1 | | Recap |
173 |
JJ Bartliff |
| 2022-01-22 15:00:0022/01/2022 | Guisborough Town | 4 - 3 | Redcar Athletic | Ebac Northern League Division 1 | | Recap |
469 |
- |
| 2022-01-25 19:45:2425/01/2022 | Pickering Town FC | 3 - 4 | Guisborough Town | North Riding Senior Cup | | Recap |
- |
- |
| 2022-01-29 15:00:0029/01/2022 | Guisborough Town | 1 - 1 | Crook Town | Ebac Northern League Division 1 | | Recap |
258 |
- |
| 2022-02-05 15:00:0005/02/2022 | Newton Aycliffe | 1 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
96 |
- |
| 2022-02-12 15:00:0012/02/2022 | Guisborough Town | 2 - 0 | Billingham Town | Ebac Northern League Division 1 | | Recap |
204 |
- |
| 2022-02-19 15:00:0019/02/2022 | Guisborough Town | 0 - 2 | Consett | Ebac Northern League Division 1 | | Recap |
270 |
JJ Bartliff |
| 2022-02-26 15:00:0026/02/2022 | Seaham Red Star | 1 - 1 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
145 |
JJ Bartliff |
| 2022-03-05 15:00:0005/03/2022 | Penrith | 2 - 3 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
130 |
- |
| 2022-03-09 19:45:5309/03/2022 | Guisborough Town | 4 - 0 | Penrith | Northern League Division One Cup | | Recap |
116 |
- |
| 2022-03-12 15:00:0012/03/2022 | West Auckland Town | 1 - 1 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2022-03-19 15:00:0019/03/2022 | Ashington | 1 - 6 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
358 |
- |
| 2022-03-26 15:00:0026/03/2022 | Guisborough Town | 1 - 1 | Whitley Bay | Ebac Northern League Division 1 | | Recap |
456 |
- |
| 2022-03-30 19:45:0130/03/2022 | Guisborough Town | 1 - 0 | Marske United | North Riding Senior Cup | | Recap |
626 |
- |
| 2022-04-02 15:00:0002/04/2022 | North Shields | 4 - 2 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2022-04-05 19:45:5405/04/2022 | Ashington | 3 - 1 | Guisborough Town | Northern League Division One Cup | | Recap |
265 |
- |
| 2022-04-09 15:00:0009/04/2022 | Whickham | 3 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
- |
- |
| 2022-04-16 15:00:0016/04/2022 | Guisborough Town | 1 - 1 | Sunderland Ryhope C.W. | Ebac Northern League Division 1 | | Recap |
242 |
- |
| 2022-04-19 19:45:0019/04/2022 | Bishop Auckland | 0 - 1 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
266 |
- |
| 2022-04-23 15:00:0023/04/2022 | Thornaby | 1 - 0 | Guisborough Town | Ebac Northern League Division 1 | | Recap |
265 |
- |
| 2022-05-04 19:30:2704/05/2022 | Guisborough Town | 0 - 3 | Scarborough Athletic | North Riding Senior Cup | | Recap |
1,387 |
Joseph Bartliff |
